Episode 53 of CRAMSURG - Clinical Research Appraisal and Methodology for Surgical Trainees. The paper for discussion is Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial, JAMA Surgery Mar 2025. The teaching topic is a practical guide to statistical tests - part 5: paired samples t test. Brought to you by CRAMSURG www.cramsurg.org.