Episode 48 of CRAMSURG - Clinical Research Appraisal and Methodology for Surgical Trainees. The paper for discussion is Predictors of appendicectomy one year after antibiotic treatment for acute appendicitis: Insights from a prospective, multicentre, observational study WJS Aug 2024. The teaching topic is surgical randomised controlled trials: real life challenges. Brought to you by CRAMSURG www.cramsurg.org.