In response to an increased risk of overdose, several communities in the U.S. are considering establishing spaces for people to use substances safely. These spaces have been referred to as Supervised Injection Facilities, safe consumption spaces, harm reduction spaces, or overdose prevention sites. Over the past few years, these spaces have garnered more support for their proven ability to reduce overdoses and meet other medical and psychosocial needs for people who use them. This month, our hosts talk through the benefits that these spaces have on HIV prevention, linkage to care and needed support services, fatal overdose prevention, and what it takes to get a sanctioned overdose prevention space in the U.S.