A 2026 randomized placebo-controlled trial just found that adaily yeast-derived nucleotide supplement
significantly improved memory and cognitive test scores inseniors with mild cognitive impairment —
in just 6 months, with zero reported side effects.
Here's what the science actually says.
📰 Study: Ullah et al.,Nutrients 2026 | https://doi.org/10.3390/nu18121869
🔬 WHAT THE STUDY FOUND
72 older adults (ages 60–85) with mild cognitive impairment(MCI) were split into three groups
for 180 days:
• Group 1:Kluyveromyces fragilis yeast extract (RiboDIET®)
• Group 2:Saccharomyces cerevisiae yeast extract (RiboMIX SC)
• Group 3: Placebo
On the Montreal Cognitive Assessment (MoCA, scored out of30):
✅K. fragilis group: +4.42 points (crossed into normal cognition range)
✅S. cerevisiae group: +3.92 points (crossed into normal cognition range)
❌Placebo group: +0.58 points (no significant change)
On the Mini-Mental State Examination (MMSE):
✅K. fragilis group: +1.62 points
✅S. cerevisiae group: +3.11 points
❌Placebo group: +0.25 points
Mental quality of life (SF-12 Mental Component Score):
✅K. fragilis: +7.50 points
✅S. cerevisiae: +9.16 points
❌Placebo: no significant change
No adverse events were reported in either supplement group.
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⚠️ IMPORTANT CAVEATS
This is a single-center, 72-person pilot trial. The resultsare encouraging but NOT yet definitive
clinical evidence. Larger multicenter trials are neededbefore firm recommendations can be made.
This video is for educational purposes — always consult yourphysician before starting any supplement.
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🧬 WHY NUCLEOTIDES?
Nucleotides are the building blocks of DNA and RNA. Whenderived from yeast, they appear to:
• Support brainmembrane phospholipid synthesis
• Promotesynaptogenesis (new synaptic connections)
• Reduceneuroinflammation
• Positivelyinfluence the gut-brain axis
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#BrainHealth #CognitiveDecline #MildCognitiveImpairment#Dementia #Nutraceuticals
#MemoryLoss #NutritionScience #ClinicalTrial#AlzheimersResearch #VHFILM
Ullah H, Cordara M, Morone MV, Piccinocchi R, De Lellis LF,Cerqua A, Baldi A, Sacchi R, Piccinocchi G, Di Minno A, et al. Effects ofNucleotide-Rich Kluyveromyces fragilis and Saccharomyces cerevisiae YeastExtracts on Cognitive Function in Older Adults with Mild Cognitive Impairment:A Randomized Placebo-Controlled Trial. Nutrients. 2026; 18(12):1869. https://doi.org/10.3390/nu18121869
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