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Academic SummaryA 2x2 factorial randomized controlled trial evaluated theeffects of 20g/day of inulin prebiotic supplementation alongside digitalphysiotherapy-supported exercise on 117 adults with knee osteoarthritis over 6weeks. Both interventions produced clinically meaningful reductions in paincompared to a maltodextrin placebo. However, only inulin improved pressure painthresholds, temporal summation, and grip strength. These physical improvementsin the inulin group were associated with increased serum levels of glucagon-likepeptide-1 (GLP-1) and short-chain fatty acids like butyrate.Formal AMA CitationKouraki A, Franks S, Vijay A, et al. Effect of PrebioticSupplementation With and Without Physiotherapy on Pain and Pain Sensitivity inPeople with Knee Osteoarthritis. Nutrients. 2026;18:714. #GutHealth #Osteoarthritis #JointPain #Prebiotics #GLP1#Inulin #PhysicalTherapy #MicrobiomeScience #ScienceTok #TheCatalyst Disclaimer: The content provided is for informational andeducational purposes only and does not constitute medical advice. Alwaysconsult with a qualified healthcare provider regarding any medical conditionsor treatment decisions. This content is generated for a non-monetizededucational platform.Alchepharma,Ralph Turchiano,citation,research,study,kneeosteoarthritis,joint pain relief,gut microbiome,prebiotic fiber,inulinsupplement,GLP-1 naturally,short-chain fatty acids,butyrate,gut-muscleaxis,physiotherapy exercise,chronic pain processing,centralsensitization,pressure pain threshold,chicory root fiber,osteoarthritisclinical trial,gut brain axis,reduce inflammation naturally,jointstiffness,lower body strength,nutritional intervention for pain