In this episode, Dr. Robert Wong from Stanford University School of Medicine discusses the importance of patient-centered care and the role of patient-reported outcomes in the comprehensive management of chronic hepatitis B. Dr. Wong explains how PROs capture patients’ perspectives on their physical, mental, and social well-being—critical yet often underrecognized components of care. He highlights three validated tools that can be easily integrated into clinical practice: the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLDQ), and the Work Productivity and Activity Impairment (WPAI) Instrument. These measures help clinicians better understand how hepatitis B impacts patients’ daily lives, guide individualized treatment decisions, and strengthen multidisciplinary care involving hepatologists, mental health professionals, nutritionists, and other specialists. By incorporating PROs into pre-visit checklists and ongoing follow-up, providers can identify barriers to treatment, improve communication, and deliver more meaningful, patient-centered outcomes.