Simms & Florio do their weekly picks in an Unbuttoned/PFT PM collaboration. Can the Lions pull off the upset in Patrick Mahomes' first NFL game in a dome? Will Danny Dimes drop an L on the Redskins? And as always, the guys give their 3 Best Bets of the week.

TNF: Eagles-Packers "Carson Wentz is the best QB the Packers have seen all year"

Panthers-Texans "This is a chance for Houston to pull away in the AFC South"

Browns-Ravens "I want to see how Freddie Kitchens handles adversity"

Chiefs-Lions "If the Lions pull this off, it would be a shot heard 'around the NFL world"

Chargers-Dolphins "I don't bet on bad teams"

Patriots-Bills "Every we think this is the year the Bills stick it to the Patriots"

Raiders-Colts "I think this Colts offense has gotten better every week"

Titans-Falcons "The Titans always play to their competition"

Redskins-Giants "I can't pick a team who stirs their Gatorade with a bag of plastic cups"

Seahawks-Cardinals "The Seahawks need to keep pace in the NFC West"

Buccaneers-Rams "There is something wrong with Todd Gurley"

Jaguars-Broncos "I don't think Jalen Ramsey will play Sunday"

Vikings-Bears "The Bears have never seen this version of Dalvin Cook"

SNF: Cowboys-Saints "We have not seen a Cowboys offense like this in a long time"

MNF: Bengals-Steelers "The Steelers are in denial about not being good"