SGLT2 inhibitors are the new drugs which have been approved for heart failure with reduced ejection fraction (HFrEF). After the landmark EMPA-REG_OUTCOME, DECLARE TIMI 58, EMPEROR REDUCED and DAPA HF trials, empagliflozin and dapagliflozin have found a place in the management of HFrEF or heart failure. Lets discover what makes them special drugs in heart failure.