Precision oncology in the treatment of solid tumors is a rapidly growing field which involves testing for molecular biomarkers. Molecular biomarkers can be used to confirm a diagnosis, provide prognostic information, and select targeted therapies. Pathologists need a working knowledge of these biomarkers and assays used for their evaluation to optimize patient care, explains Jennifer Yoest, MD, FCAP, a pathologist at UH Cleveland Medical Center, in this CAPcast. Dr. Yoest, who led the development of a Clinical Pathology Improvement Program course on this topic (https://capatholo.gy/3187OsM), will also discuss how this knowledge will also help pathologists triage specimens and prioritize testing in situations where limited tissue is available, which is also known as tissue stewardship.