Evolving regulatory guidance, changing reimbursement rules, staffing shortages and other concerns are creating more challenges for laboratory leaders. The latest edition of the Laboratory Administration for Pathologists (https://capatholo.gy/2F1uLzT) provides laboratory managers with practical knowledge to identify situations which could lead to sanctions as well as strategies to improve their laboratory. Understanding and responding to changes in regulation can help to improve patient safety, ensure laboratory viability and reduce risk of sanctions or loss of accreditation, explains leading pathologist and co-author of this second edition, Dr. Elizabeth Wagar in this CAPcast.