Discussing the subject of an autopsy can be a very difficult process for both the bereaved family member being asked and for the health care professional making the request. In this CAPcast, Dr. Harold Sanchez, a member of the CAP's Autopsy Committee, and Dr. Tom Smith, an oncologist and the Director of Palliative Care at Johns Hopkins Medicine in Baltimore, discuss the consent process for the performance of a hospital autopsy as well as advice on how to best navigate the process with family members.