In the second installment of this two-part series, the Brown Surgery podcast continues its discussion with Dr. Manuel Portalatin, DO to discuss the definitive inpatient management of severe burn injuries. Dr. Portalatin breaks down the modern nuances of fluid resuscitation algorithms, explaining how teams balance the Parkland formula against the dangers of over-resuscitation, and how hourly urine output serves as the primary metric for titration. We also dive into the critical timing of nutrition, the physiological impact of "rescue albumin" on the endothelial glycocalyx, and the surgical nuances of excision and grafting. From traditional topicals to advanced dermal templates like BTM and emerging enzymatic debridement technologies like Nexobrid, this episode provides a comprehensive guide to long-term scar mitigation, contracture management, and laser modalities.