When cancer spreads to the brain, what is the best approach: immediate local treatment or systemic immunotherapy first? Part two of the 2025 NSCLC Creator Weekend™ series focuses on a complex case involving a 75-year-old woman with a history of breast malignancy, presenting with new dyspnea and a large mass in the left lower lobe.---This podcast is supported by an educational grant from Johnson & Johnson and Varian.---SYNPOSISOur mock tumor board consists of surgeons, medical oncologists, and radiation oncologists to deliberate and determine the best treatment plan. The specialists explore diagnostic and treatment options, including neoadjuvant chemoimmunotherapy, invasive mediastinal staging, and the potential for surgical resection or radiation therapy.---TIMESTAMPS---RESOURCESPACIFIC Clinical Trialhttps://www.nejm.org/doi/full/10.1056/NEJMoa1709937