The human neuroendocrine system is directly regulated and in communication with the  autonomic nervous system via cortical and diencephalonomic CNS nuclei. These converging networks coordinate satiety, glycemia, bioenergetics, oxygen transport, dietary input, digestion and muscular activity in direct association with pancreatic insulin/glucagon ratio dynamics.

 References

Molecular Neurobiology volume 56, pages769–796 (2019)

Molecular Neurobiology volume 56, pages7950–7965 (2019)