That there are senescence-associated  decreases in the JAK-STAT signaling transduction cascade has been observed in human lymphocyte lineages. This phenomena, as  associated with a decreased JAK- tyrosine phosphorylation of STAT5, is linked to plasma membrane cholesterol content. Therefore, plasma membrane cholesterol content is involved in T cells modulation and proliferation.

Acid sphingomyelinase- mediated ceramide lipid raft mobilization and aggregation of membrane receptors plays a crucial role in this pathobiochemical dynamic leading to multiple disease and comorbidity states in the elderly.

Classical Papers Examined:

Mech Ageing Dev. 2001 Sep 15;122(13):1413-30

Cytometry A. 2006 Mar;69(3):189-91

J Lipid Res. 2007 Jan;48(1):19-29. doi: 10.1194