1. Glucokinase- GK is in the neuron

2.Control over glycolysis via GK mediates neural transmission

3.  Neuronal GK further functions on  the appetite/satiety axis thus partially regulating the HPA axis

4. Aging and immune associated dysfunction of these glycolytic systems are associated with neurodegeneration and the loss of neuronal action potential mediated learning, memory, and mood.

Therefore, metabolic control over the severity of chronological age and the immunosenescence of the CNS can be exacerbated by visceral obesity thus linking CNS decline to the major causes of morbidity and mortality in the aging human population.

Curr Opin Lipidol. 2015 Apr; 26(2): 88–95

Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E42–E55