During thymic T lymphocyte recombinatorial self avoidance, the  processing  obtained in T cell receptor excision generates small circular DNA byproducts that may be used as a biomarkers for thymic output and for the relative ability of T lymphocytes to fight infection, tumors, and obesity -linked cardiovascular disease and metabolic disorders  that may become important pathologies in the aging human population.

Transcription factors like Nfil3 are important components of this networked  age-related decline called immunosenescence that has the pathobiochemical signatures of SASP , ROS, mutation, epimutation and epigenetic gene expression pathologies.

Dr. Daniel J. Guerra Authentic Biochemistry Podcast Publication. 14 November 2020

References

Braz J Med Biol Res. 2019; 52(7): e8292

PLoS One. 2016; 11(6): e0157930

Experimental & Molecular Medicine volume 51, Article number: 80 (2019)