AJPH's Vickie Mays and Alfredo Morabia had an in-person conversation with Derek M Griffith, PhD, Center for Men's Health Equity about what it takes to achieve the goal of the center, equity in men's health. Dr Griffith reflects on the importance of the inclusion of concepts of manhood, trustworthiness, intersectionality, and individual tailoring that can be incorporated into community-based and policy strategies to promote health and well-being, particularly for African American men.