Co-Editor-in-Chief Jasmohan Bajaj and Dr Philip Katz of Weill Cornell Medicine discuss the recently published ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. First author Dr. Katz discusses how PPIs remain the medical treatment of choice for GERD even though multiple publications question potential adverse events. The guideline addresses key issues in PPI management and adverse events, so clinicians will have a comprehensive, go-to source in the guideline. (16:43)

Divyanshoo R. Kohli, MD of the Kansas City VA Medical Center in Missouri, discusses his publication of a retrospective analysis and comparison of outcomes of PEG and IRG using an integrated nationwide database. (19:29)

Co-Editor-in-Chief Brennan Spiegel, MD, MSHS, FACG interviews Arnold Wald, MD, MACG to discuss highlights from the ACG Clinical Guideline Management of Benign Anorectal Disorders, published in the October 2021 issue of the American Journal of Gastroenterology. Download slides summarizing key concepts and treatment recommendations for proctalgia syndromes, chronic anal fissures, and hemorrhoids to follow along with this podcast. (31:18)

Binu V. John, MD, MPH joins Co-Editor-in-Chief Brian Lacy, MD, PhD, FACG to discuss the retrospective study conducted through the US Veterans Administration which examined the association of ursodeoxycholic acid liver-related death, hepatic decompensation, and hepatocellular carcinoma in patients with primary biliary cirrhosis. (23:28)

Ira Jacobson, MD, FACG joins Co-Editor-in-Chief Brian Lacy to discuss the recently published article on the clinical features and prognostic implication of cholangiopathy after severe COVID-19. (29:49)

Colleen Kelly, MD, FACG joins Co-Editor-in-Chief Brian Lacy, MD, PhD, FACG to discuss the preferred approach to the management of adults with C. difficile infection taken from the ACG Clinical Guideline. (21:48)

Shanti Eswaran, MD and Co-Editor-in-Chief Brennan Spiegel, MD discuss the new study on how kiwifruit can improve symptoms in patients with chronic constipation. (15:58)

Loren Laine MD, FACG joins Co-Editor-in-Chief Brennan Spiegel, MD, MSHS, FACG to discuss the ACG Clinical Guideline "Upper Gastrointestinal and Ulcer Bleeding." Dr. Laine discusses risk assessment in the emergency department in order to identify very-low-risk patients who may be discharged, as well as the recommendation for high-dose PPI therapy after endoscopic hemostatsis. (25:55)

K. Rajender Reddy MD, FACG speaks with Co-Editor-in-Chief Brian Lacy, MD on the new ACG Guideline Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. Dr. Reddy offers clinical pearls of wisdom for diagnosing drug-induced liver injury in patients and reviews the new recommendations. (24:17)

Amol Agarwal, MD talks with Co-Editor-in-Chief Brennan Speigel, MD on whether or not the use of mt-sDNA testing in the primary care setting is an appropriate diagnostic tool for colorectal cancer screening.(16:40)