In this study, the authors first sought to empirically derive centiles for heart rate (HR), respiratory rate (RR), and systolic blood pressure (SBP) for adults with out-of-hospital emergencies who were transported to an ED. Second, they aimed to evaluate the impact of adjusting for age in the evaluation of centile curves for vital signs to identify practical targets for adjustment of vital signs classification in adult patients based on age categories. Third, they examined the association of both unadjusted and age-adjusted vital signs with hospital admission and in-hospital mortality.