This episode of ACCESS, the official podcast of Stroke: Vascular & Interventional Neurology, provides an overview of the sixth issue of 2024. Highlights of the journal with summaries of the latest advances in vascular and interventional neurology by Editor-in-Chief, Dr. Ashutosh Jadhav followed by a discussion with Dr. Claus Simonsen and Dr. Max Mokin on the recently published endovascular therapy in acute ischemic stroke patients with large infarct.