Abel James Show
Abel James Show
Abel James
Donnie Yance: Why Microdosing is More Effective Than Macrodosing
1 hour 15 minutes Posted Dec 4, 2025 at 6:16 pm.
Opening question: microdosing vs. macrodosing
Simple practices: breath, gratitude, prayer, parasympathetic
Guest intro: Donnie Yance, herbalist, nutritionist, funk monk
Aging as a pilgrimage and the paradox of health
Joy, connection, and Blue Zones over elite longevity hacks
Hormesis, adaptogens, and the six toolboxes of care
Wisdom guiding science; unifying modern and traditional medicine
Polypharmacy pitfalls and dose matters in oncology
Why microdosing works; melatonin dosing debate
Humble medicine: strengthen roots, not quick fixes
What makes an adaptogen: the three Ns and HPA support
Xenohormesis, weeds, and the beauty of humble foods
Vagus nerve, prayer, nervines, and real digestion
Getting off PPIs safely and rebuilding the gut
Peptides vs. precursors: amino acids that build resilience
Adaptive capacity: life force, yin3yang, and flexibility
Stimulants, energy drinks, and safer boosts
Frankincense, myrrh, and sacred aromatics for healing
We know enough: network medicine over magic bullets
Bees gifts, starch, seasons, and personalized diets
Music, medicine, and why they belong together
Creating authentically in a high tech world
Closing thoughts and where to find Donnie
Outro and ways to support the show
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Show notes
Is microdosing more effective than macrodosing?

While heavy-handed megadoses of synthetic pharmaceuticals attempt to dominate a single biochemical pathway, microdoses of synergistic botanticals can stimulate the body to normalize, balance and heal itself.

Meanwhile, much of modern medicine has devolved into a game of manipulating numbers on blood tests rather than actually healing you.

Because they're not so easily patented and monetized, many of the most effective, affordable and simple substances and practices in health and longevity are dismissed, ignored, or at the very least taken for granted.

For instance, did you know that the simple act of prayer has been scientifically proven to not only improve mental health, but also improve the literal physical health of the heart?

Deep breathing, gratitude, meditation, and prayer steady the vagus nerve and allow our bodies to remain flexible and adaptable, downregulating our nervous system from fight-or-flight into a relaxed parasympathetic state.

The truth is, we don't need to wait for the next miracle pill to save us. We already know more than enough to put life-saving practices into action today.

Donnie Yance is a Clinical Master Herbalist, Certified Nutritionist and Author, known internationally for his pioneering work in botanical and nutritional medicine, particularly in the field of integrative cancer. As an accomplished jazz bassist and former monk, Donnie is also known as "The Funk Monk."

In this episode, you'll discover:
  • How to eat and supplement for greater adaptive capacity, hardiness, and resilience
  • Why many of the secrets to long life lie in humble living
  • How Donnie earned the nickname of "The Funk Monk"
  • How improvisation in music mirrors the intellectual and playful flexibility we need in health
  • And much more...
Find Donnie Yance and his work at: 
Books by Donnie Yance: 
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