A Chat with Uma
A Chat with Uma
Uma R. Chatterjee, M.S., MHPS
18. The Real OCD Chemical Imbalance: Glutamate, GABA, & Becoming An OCD Neuroscientist with Dr. Ana Maria De Souza
1 hour 34 minutes Posted Jul 20, 2023 at 5:01 am.
) Introduction of episode & Dr. Ana Maria De Souza
): Dr. De Souza's lived experience with conditions and how that led her to become a neuropsychologist
): How Dr. De Souza then pivoted from neuropsychology/clinical practice to cognitive neuroscience
): How Dr. De Souza began studying OCD
): Dr. De Souza's operational definition and conceptualization of OCD as a neuropsychologist, cognitive neuroscientist, and researcher (important to listen to!)
): The neuroscience of OCD, in the context of Dr. De Souza's research + work; Differentiating OCD from anxiety/anxiety disorders
): Newest unpublished findings from Dr. De Souza's lab and research!
): Dr. De Souza & colleagues' newest (+ groundbreaking!) Nature paper on Glutamate + GABA chemical imbalances in OCD patients
): The critical importance of science communication and consuming research responsibly
): Limitations, caveats, and considerations around Dr. De Souza & colleagues' findings; limitations on research in general, at this time
): DEEP rapid-fire final questions with Dr. De Souza, and closing out the episode!
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Show notes
On episode 18 of A Chat with Uma, I speak with Dr. Ana Maria De Souza! Ana Maria De Souza, Ph.D, is a Brazilian cognitive neuroscientist, who is passionate about bridging the gap between researchers, clinicians, and the public. She has completed an undergraduate degree and a Master's in Psychology in Brazil, and moved to the UK to pursue a Ph.D at the University of Cambridge with some of the most renowned OCD researchers in the world. She is committed to translating brain research into publicly available treatments for OCD and empowering individuals to make fully informed choices.
In this episode, we discuss the following topics (+ timestamps):
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From anxiety to OCD
Combatting the misconceptions and stigma around OCD
How OCD is not usually taught about accurately in higher education
How her understanding of OCD completely changed from meeting patients
Her deep respect for and protectiveness of OCD survivors
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00:27:07): Dr. De Souza's operational definition and conceptualization of OCD as a neuropsychologist, cognitive neuroscientist, and researcher (important to listen to!)
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Differential profiles of functional vs. dysfunctional patient subgroups + theories
Speculation around differences in themes and physical vs. mental compulsions
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Paper: Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
Discussion of novel methods
Results and implications for patients
Consequences of treatment delays on symptom severity
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01:07:56): The critical importance of science communication and consuming research responsibly
Misinterpretation of research findings
Unfounded conclusions
Correlation vs. causation
Why we can't immediately translate basic science findings to treatments
Consequences of incorrect science dissemination + interpretation
The vast complexity and nuance of scientific findings
The pitfalls of advocacy, overenthusiasm, and inadvertently communicating inaccurate research
How to make research more accessible in an evidence-based, science-informed way
Guidance on how to actually read research papers!
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Connect with Dr. Ana Maria De Souza:
⁠Instagram:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@OCD_science
Dr. De Souza on ⁠ResearchGate⁠
Paper: Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls ⁠
Orchard Registry: for patients to participate in OCD research
Connect with me!
My website⁠: ⁠⁠⁠⁠⁠⁠⁠⁠⁠umarchatterjee.com⁠⁠⁠⁠⁠⁠⁠⁠⁠
⁠Instagram:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠
Twitter:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠
TikTok:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠
Email: ⁠⁠⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠
Have a guest you want on the show? Fill out the ⁠⁠⁠Guest Suggestion Form!⁠