This Week In Startups is made possible by:Plaud: https://plaud.ai/twistOdoo: https://odoo.com/twistNorthwest Registered Agent: https://www.northwestregisteredagent.com/twistdomainQuo: https://www.quo.com/perks/twistToday’s show:A personal AI agent that’s still invite-only just hit a $10 billion valuation. Guest host Deedy Das of Menlo Ventures is joined by Kanu Gulati of Khosla Ventures, Chris Farmer of SignalFire, and Sheel Mohnot of Better Tomorrow Ventures to debate whether Instinct can beat Meta’s Muse, what they actually use their own agents for, and what breaks when everyone’s agent makes the same move.Plus we’re also talking about OpenAI’s math breakthroughs, the Factory vs. Cognition fight, and whether SaaS is still worth funding. Catch the whole debate on this week’s VC roundtable.Guests:Deedy Das on X: https://x.com/deedydasMenlo Ventures: https://menlovc.comKanu Gulati on X: https://x.com/KanuGulatiKhosla Ventures: https://www.khoslaventures.comChris Farmer on X: https://x.com/chriswfarmerSignalFire: https://www.signalfire.comSheel Mohnot on X: https://x.com/pitdesiBetter Tomorrow Ventures: https://www.btv.vcRelevant Links:OpenAI’s 722 math manuscripts from an unreleased internal model → https://github.com/openai/mathOpenAI’s earlier Navier–Stokes Millennium Prize result → https://openai.com/index/navier-stokes-solution/Pramaana Labs, the Khosla-backed startup turning tax rules into provable logic → https://pramaanalabs.aiLogos Research, the Imperial College spinout verifying AI-written financial code → https://www.imperial.ac.uk/news/articles/2026/logos-research-plans-to-make-ai-reasoning-trustworthy-in-high-stakes-environments/EvenUp, SignalFire’s AI company for personal injury law → https://www.evenuplaw.com/WindBorne Systems, the Khosla-backed weather balloon company Kanu mentioned → https://windbornesystems.comGokul Rajaram’s X Post: https://x.com/gokulr/status/2107851356019290569?s=20micro1, the AI training data company Chris and LAUNCH backs → https://www.micro1.aiVercel’s data on companies shifting to open-weight models → https://vercel.com/i/open-weight-modelsInstinct raises $1B at a $10B valuation (SiliconANGLE) → https://siliconangle.com/2026/09/28/everyday-personal-ai-assistant-startup-instinct-raises-1b-at-10b-valuation/Meta introduces Muse, its personal AI agent → https://about.fb.com/news/2026/09/introducing-muse-personal-ai-agent/Wajo, maker of the Fo agent Kanu uses → https://wajo.aiFactory’s CEO accuses his board adviser of spying for Cognition (TechCrunch) → https://techcrunch.com/2026/09/30/factory-ceo-just-accused-his-vc-board-advisor-of-spying-for-cognition/xAI rents its Colossus 1 data center to Anthropic (Data Center Dynamics) → https://www.datacenterdynamics.com/en/news/musk-spacex-xai-is-actively-seeking-more-ai-compute-customers-following-anthropic-deal/Bending Spoons agrees to buy Miro, weeks after Airtable → https://investors.bendingspoons.com/newsroom/bending-spoons-agrees-to-acquire-miroThe FCC’s new rule on foreign-made robots → https://www.fcc.gov/covered-list-faqs-robots-invertersTimestamps:Subscribe to our newsletters on Substack:TWiST: https://twistartups.substack.com/TWiAI: https://www.thisweekinai.ai/TWiVC: https://thisweekinvc.substack.com/Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:Check out all our partner offers: https://partners.launch.co/