This Week in Startups
This Week in Startups
Jason Calacanis
Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334
58 minutes Posted Sep 4, 2026 at 4:44 pm.
What Function actually is
Healthspan vs. sick care
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A $300 vitamin D test vs. a $10 one
Should a 25-year-old get a whole-body MRI?
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Why medicine is still running on paper
The study where the chatbot beat the doctors
micro1, doctors in the loop, and why AI still needs guardrails
Wearables, records, and the CD-ROM problem
Rippling Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business.
The wearable that caught Jason's Covid
Alcohol, sugar, and why almost nobody tests your insulin
GLP-1s: Jason's 213-to-168 story
Microdosing GLP-1s, muscle loss, and "skinny fat"
Overdiagnosing mental illness: SSRIs, Adderall, and a lost decade
The biology underneath depression and anxiety
Psychedelics: ketamine, ibogaine, and the second revolution in psychiatry
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Today's show:
Your doctor almost certainly isn't testing your insulin. Dr. Mark Hyman sits down with Jason to explain the broken system that Function is fixing, and what 100 million biomarkers say about how sick America actually is.
Learn why insulin beats blood sugar as an early warning for TKTKTK. Why might "normal" lab ranges be unreliable? PLUS, how does an expert like Dr. Hyman feel about GLP-1s and psychedelics?
Guests:
Dr. Mark Hyman on X: https://x.com/drmarkhyman
Function: https://www.functionhealth.com/
Relevant Links:
The Dr. Hyman Show — https://podcasts.apple.com/us/podcast/the-dr-hyman-show/id1382804627
Function pricing — https://www.functionhealth.com/pricing
Ezra — the full-body MRI company Function acquired https://ezra.com/
Galleri (GRAIL) — the multi-cancer early detection blood test — https://www.galleri.com/
Tufts / JACC study — the source of the "93% of Americans have metabolic dysfunction" — https://now.tufts.edu/2022/07/05/only-7-american-adults-have-good-cardiometabolic-health
American College of Cardiology — https://www.acc.org/
Dr. Jorge Plutzky — https://www.health.harvard.edu/authors/jorge-plutzky-md
OpenEvidence — https://www.openevidence.com/
Stanford Metabolic Psychiatry Clinic — https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html
Stanford Medicine on the ibogaine findings → https://med.stanford.edu/news/all-news/2024/01/ibogaine-ptsd.html
Texas SB 2308 — the $50M state investment in ibogaine trials — https://www.texastribune.org/2026/03/31/texas-ibogaine-research-clinical-trials-psychedelics/
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