Psychopharmacology for those that experience severe and persistent mental illness is a complex issue. In this training, we will begin by discussing the barriers to medication adherence. Specifically, the side effects of medications themselves, the historical impact of unethical medical practices and research, and the difficulties in building trust with our clients as a result. Acknowledging the common misbeliefs that are held about medications, which are often exacerbated by symptoms of mental illness will be a focal point of this training. Finally, by developing an understanding of the positive outcomes that derive from medication adherence, we can introduce potential solutions for clients that are struggling with medication non-adherence.