Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+
Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+
Everyday Wellness™
Ep. 557 “Your Hormones Are Hijacking Your Mood!” – The Shocking Way to Reduce Anxiety, Depression & Insomnia in Perimenopause
20 minutes Posted Feb 19, 2026 at 8:00 am.
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Show notes
Welcome to this week’s Midlife Minute episode.
We’re focusing on the importance of having good mental health today. Statistics show that women are experiencing increased anxiety, depression, insomnia, and even suicidal thoughts during midlife, yet the stigma around mental health remains surprisingly strong.
Join me as I explore the science behind this, why it’s happening, and the importance of empowering yourself to demand better care.
IN THIS EPISODE, YOU WILL LEARN:
The issues that contribute to the midlife mental health challenges women are experiencing
How sleep disruptions in perimenopause increase anxiety, depression, and irritability
The metabolic and endocrine factors that can compound mood instability in midlife
Why perimenopause is a neurological as well as reproductive transition
The evidence-based benefits of HRT for supporting mental health
The role of estrogen in brain function and emotional regulation
Why HRT is especially important for women experiencing abrupt or early menopause
Some practical guidance for using HRT to support mental health
Connect with Cynthia Thurlow  
Follow on X, Instagram & LinkedIn
Check out Cynthia’s website.
Submit your questions to [email protected]
Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.
Cynthia’s Menopause Gut Book is on presale now!
Cynthia’s Intermittent Fasting Transformation Book
The Midlife Pause Supplement Line
References:
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2298235) 
Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers (https://onlinelibrary.wiley.com/doi/10.1002/da.22391)
Effects of Hormone Therapy on Cognition and Mood (https://www.fertstert.org/article/S0015-0282(14)00178-2/fulltext)
Does Menopause Hormone Therapy Improve Symptoms of Depression? Findings From a Specialized Menopause Clinic 
A Meta-analysis of the Effect of Hormone Replacement Therapy upon Depressed Mood (https://www.sciencedirect.com/science/article/abs/pii/S0306453096000340?via%3Dihub)
The Effect of Hormone Replacement Therapy on Cognition and Mood (https://onlinelibrary.wiley.com/doi/10.1111/cen.14856)