The Incubator
The Incubator
Ben Courchia & Daphna Yasova Barbeau
#469 - [Journal Club] - 📌 Early ibuprofen or waiting, does the PDA choice show up at two years?
24 minutes Posted Sep 28, 2026 at 6:00 am.
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Send us Fan Mail In this Journal Club episode, Ben and Daphna review the 24-month follow-up of the BeNeDuctus trial, which compared expectant management with early ibuprofen for PDA in infants born before 28 weeks. Survival without neurodevelopmental impairment was identical in both groups, at 49%. Ben places the findings alongside Baby-OSCAR, the PDA trial, TRIOCAPI, and SMART-PDA, and explains why a neutral result does not mean no PDA should ever be treated. The conversation then turns to h...