The Incubator
The Incubator
Ben Courchia & Daphna Yasova Barbeau
#434 - [Journal Club] - 📌 LISA and Caffeine Together: What Do the Two-Year Outcomes Actually Show?
20 minutes Posted Apr 16, 2026 at 6:00 am.
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Send us Fan Mail In this Journal Club episode, Ben reviews a secondary analysis of the CALI trial, published in JAMA Network Open, examining two-year neurodevelopmental and pulmonary outcomes in preterm infants who received early caffeine combined with LISA versus caffeine and CPAP alone. Building on the original CALI trial's finding that early caffeine prior to LISA reduced intubation rates and BPD, this follow-up asks the next logical question: does that early advantage translate into bette...