Professor Susan Lea, Professor Christoph Tang, Professor Jeffrey Almond and Dr Ian Feavers discuss strategies for vaccines for the 21st century. Vaccines have saved an estimated 500 million lives around the world since Edward Jenner discovered how to prevent smallpox infection in 1796. But a successful vaccine roll-out is about more than just medicine; it encompasses engineering, economics, policy, government and even transport infrastructure. More than a decade into the 21st century, and with a new outbreak of the Ebola virus claiming thousands of lives in Africa, does a successful strategy for creating and delivering new vaccines require a whole new approach? Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/