This is my review of Zeposia (Ozanimod), a new once a day oral medication for moderate to severe ulcerative colitis. I go over the True North Study (https://www.nejm.org/doi/full/10.1056/NEJMoa2033617) in detail including efficacy and safety data. I have no conflicts of interest with any pharmaceutical companies. These are my opinions regarding Zeposia and other medications based on my personal/clinical experience and review of the literature.