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In this episode, David Watkins, professor of pathology at George Washington University, shares how insights from his HIV and Zika virus research could apply to SARS-CoV-2 protection strategies. David introduces monoclonal antibodies as an intervention to prevent and treat COVID-19 infection, and also discusses how they could be used as a hedge to vaccine development. Additionally, David’s immunology tutorial explains the innate and adaptive immune systems and their differentiated responses to viral infection.   We discuss: Background and current interest in immunology [4:30]; Immunology 101—The innate and adaptive immune system [10:15]; Defining antibodies, importance of neutralizing antibodies, and serology testing for COVID-19 [19:00]; B cells—How they fight viruses, create antibodies, and fit into the vaccine strategy [25:00]; T cells—Role in the adaptive immune system and ability to kill infected cells to prevent viral spread [36:15]; Valuable lessons from HIV applied to SARS-CoV-2 [51:00]; Lessons taken from the hepatitis C success story [1:01:30]; Monoclonal antibodies, vaccines, and the most promising strategies for preventing and treating COVID-19 infection [1:04:45]; COVID-19 vaccines in development [1:19:00]; How David’s work with Zika virus informs his thinking on SARS-CoV-2 [1:25:20]; Why a vaccine for COVID-19 doesn’t need to be perfect to be effective [1:27:45]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/davidwatkins Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health. We discuss:   Eileen’s discovery that a specific oncogene blocks apoptosis [3:40]; Defining apoptosis and its role in cancer prevention [10:00]; How cancer cells use the autophagy pathway to survive [17:20]; Stressors that induce autophagy [29:15]; The importance of autophagy in the brain and liver [32:45]; The mechanisms that can trigger autophagy to support longevity [40:00]; Evidence for cancer treatment by blocking autophagy [42:30]; Types of cancer that are most autophagy-dependent [46:45]; The autophagy paradox [52:40]; Finding a molecular signal for autophagy [59:15]; Current knowledge gaps around fasting as a tool for longevity [1:13:00]; Rapamycin, metformin, and other molecules that may induce autophagy [1:22:15]; How to study fasting and exercise as longevity tools [1:32:50]; The Nobel Prize for autophagy research [1:36:45]; Eileen’s future areas of research [1:38:25]; A fasting strategy for Alzheimer’s Disease prevention[1:49:25]; Future study of metabolism and autophagy [1:51:30]; and More.  Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/eileenwhite  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things. Some of the topics that came up as a result of the questions submitted include: 00:04:03 - Data surrounding SARS-CoV-2 duration 00:06:37 - SARS-CoV-2 and potential immunity 00:11:35 - Some of the main factors known to play a role in immune variation 00:12:05 - What role genetics may play in immune function 00:14:27 - How previous viral exposure regulates immunity 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 - How sleep is a key regulator of immune function 00:23:44 - Microbiome composition and immune function 00:28:31 - The differential effects of exercise intensity and duration on immune regulation 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 - The effect of sex hormones on immune function 00:48:55 - How biological age age may play a role in immune regulation 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 - ARDS and long-term lung damage Get our detailed summary, timeline, references and more on the FoundMyFitness episode page. This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out. Learn more about this free report by clicking here. If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.
Addressing The Underlying Causes Of Infertility with Dr. Elizabeth Boham | This episode is sponsored by Inner.UAbout 10% of women of reproductive age are struggling with infertility and that number is on the rise. Individuals struggling with infertility can often feel hopeless. And while there is no across the board explanation for what causes infertility, by looking at the underlying issues that may be factoring in, it can often be reversed. In this mini-episode, Dr. Hyman is joined by Dr. Elizabeth Boham to discuss the Functional Medicine approach to treating infertility. They discuss specific patient cases and share why it is important to consider a wide range of factors including toxin exposure, nutritional deficiencies, stress management, and more.  Elizabeth Boham is a physician and nutritionist who practices functional medicine at The UltraWellness Center in Lenox, MA. Through her practice and lecturing she has helped thousands of people achieve their goals of optimum health and wellness. She witnesses the power of nutrition every day in her practice and is committed to training other physicians to utilize nutrition in healing. Dr. Boham has contributed to many articles and wrote the latest chapter on Obesity for the Rankel Textbook of Family Medicine. She is part of the faculty of the Institute for Functional Medicine and has been featured on the Dr. Oz show and in a variety of publications and media including Huffington Post, The Chalkboard Magazine, and Experience Life. Her DVD Breast Wellness: Tools to Prevent and Heal from Breast Cancer explores the functional medicine approach to keeping your breasts and whole body well. In this episode, Dr. Hyman and Dr. Boham discuss:Why infertility may be on the riseThe difference between the traditional and Functional Medicine approach to infertilityReasons why people may struggle with infertility including diet, toxin exposure, nutritional deficiencies, stress management, exercise, sleep, and moreWhat your waist to hip ratio and body composition can tell youHow insulin and thyroid issues can affect fertilityCeliac disease and nutrient deficienciesThe importance of good prenatal vitamins with folateFor more information visit drhyman.com/uwc When you sign up for Inner.U LIFE , you get a lifetime subscription to the program, 1 free session with an Handel Group Certified Coach, and access to Inner.University, with a 6-week coaching Masterclass to kick start your journey in the program. You can now get Inner.U Life for half off using code HYMAN75. Just visit https://www.handelgroup.com/markhyman to get Inner.U Life for only $325. The next Masterclass kicks off on July 1.Additional resources:Is An Underactive Thyroid To Blame For Your Mysterious Symptoms? with Dr. Elizabeth BohamThe Underlying Causes and Solutions for Women’s Hormonal Balances with Dr. Elizabeth BohamClara’s Case Study: Overcoming Infertilityhttps://www.ultrawellnesscenter.com/2018/09/05/claras-case-study-overcoming-infertility/A Functional Medicine Approach to Infertilityhttps://www.ultrawellnesscenter.com/2018/09/01/a-functional-medicine-approach-to-infertility/Supporting the Thyroid: Food as Medicinehttps://www.ultrawellnesscenter.com/2018/03/15/supporting-thyroid-food-medicine/Stop Drinking Your Calorieshttps://www.ultrawellnesscenter.com/2018/03/05/stop-drinking-calories/7 Strategies to Reverse Infertilityhttps://drhyman.com/blog/2015/10/14/7-strategies-to-reverse-infertility/Food, Fat, and Infertilityhttps://drhyman.com/blog/2017/06/05/food-fat-infertility/ See acast.com/privacy for privacy and opt-out information.
"In the United States, we have a relatively low threat history. We're separated by two oceans from other continents. We haven't been afraid of Canada, Mexico, chronically invading us. We haven't been afraid of constant fury from mother nature. And so, as a result, we have a harder time tightening up than other countries under these conditions because it's hard for people to sacrifice the kind of liberty and freedom that we've had for constraints and rules.” - Michele Gelfand In today’s episode, our host Dr. Celine Gounder and former co-host Ron Klain interview two experts, Michele Gelfand and Howard Lavine, about why Republicans and Democrats are so deeply divided over almost everything to do with COVID. They discuss the shift towards identity politics and why people tend to vote along the lines of their chosen political party instead of in their best personal interests, and how this complicates different states’ responses to COVID. They also examine how a community’s history of threats in the past shapes their response to crises today. Michele Gelfand is a professor of psychology at the University of Maryland, and is the author of "Rule Makers, Rule Breakers: How Tight and Loose Cultures Wire Our World." Howard Lavine is the Associate Dean of Social Sciences and a professor of political science and psychology at the University of Minnesota. He's the co-author of the book "Open Versus Closed: Personality, Identity, and the Politics of Redistribution,” and the editor of the journal Advances in Political Psychology. This podcast was created by Just Human Productions. We're powered and distributed by Simplecast. We're supported, in part, by listeners like you. #SARSCoV2 #COVID19 #COVID #coronavirus
Meat That Is Good For You And The Planet with Fred Provenza | This episode is brought to you by Thrive Market, Joovv, and chiliEating a variety of phytonutrients is a powerful way to support optimal health, from things like colorful fruits and veggies. Another really cool side of phytonutrients is the impact they have on making animals healthier, too. In fact, animals who graze on a diverse variety of pasture, with lots of different kinds of wild plants, get an incredible array of phytonutrients. They will even intuitively mix and match their nutritional needs to what plants are available, making sure they get the right balance of vitamins and minerals. Animals who’ve been able to graze like this provide much healthier meat that passes more nutritional benefits along to us. Plus they get to live happier, more natural lives! Today on The Doctor’s Farmacy, I talk to Fred Provenza about the amazing world of phytochemicals and what they can do for animals and our own bodies. Fred grew up in Salida, Colorado, working on a ranch and attending school in WildlifeBiology at Colorado State University. He is professor emeritus of Behavioral Ecology in theDepartment of Wildland Resources at Utah State University where he worked for 35 years,directing an award-winning research group that pioneered an understanding of how learninginfluences foraging behavior and how behavior links soil, plants, herbivores, and humans.He is the author of three books, including Nourishment: What Animals Can Teach Us AboutRediscovering Our Nutritional Wisdom; Foraging Behavior: Managing to Survive in a World ofChange; and The Art & Science of Shepherding: Tapping the Wisdom of French Herders (co-authored with Michel Meuret). He has also published over 300 research papers in a wide variety of scientific journals.This episode was sponsored by Thrive Market, Joovv, and chili.Thrive Market has made it so easy for me to stay healthy, even with my intense travel schedule. Not only does Thrive offer 25 to 50% off all of my favorite brands, but they also give back. For every membership purchased, they give a membership to a family in need. Get up to $20 in shopping credit when you sign up and any time you spend more than $49 you’ll get free carbon-neutral shipping. All you have to do is head over to thrivemarket.com/Hyman.I recently discovered Joovv, a red light therapy device. Red light therapy is a super gentle non-invasive treatment where a device with medical-grade LEDs delivers concentrated light to your skin. It actually helps your cells produce collagen so it improves skin tone and complexion, diminishes signs of aging like wrinkles, and speeds the healing of wounds and scars. Check out the Joovv products at joovv.com/farmacy and use the code FARMACY at checkout.One of the easiest and most effective ways to get better sleep every single night is through temperature regulation, which is why I was so relieved to discover the transformative products from Chili. The chiliPAD and OOLER system are two really cool gadgets that fit over the top of your mattress and use water to control the temperature of your bed—which helps lower your internal temperature and trigger deep relaxing sleep. Right now chili is offering my audience a really great deal. Get 25% off the chiliPAD with code hyman25 or 15% off OOLER with code hyman15, just go to chilitechnology.com/drhymanHere are more of the details from our interview: How Fred started thinking about the relationship between phytochemicals, plant diversity, and animal health (8:08)Nutrient deficiencies in animals and in humans that have resulted from industrial agriculture and mono diets (13:32)How animals naturally meet their nutritional requirements by eating a diversity of plants (17:58)How palatability illustrates our innate nutritional wisdom, and the innate nutritional wisdom of animals (23:40)What animals in feedlots are fed (30:50)The four reasons why food quality has declined from our modern agricultural practices (34:10)Is eating grass-fed meat better for our health, and is all grass-fed meat created equal? (41:39)Would it be better for the environment if humans stopped eating meat altogether? (52:43)Are we eating too much meat? (1:05:58)What you eat with meat, and spices may influence the effects of meat on our health (1:11:45)Flavor is developed in utero and early in life (1:19:02)Get Fred’s book, Nourishment: What Animals Can Teach Us about Rediscovering Our Nutritional Wisdom via Chelsea Green here, at Barnes & Noble here, and via Amazon hereFind Fred’s paper, “Is Grassfed Meat and Dairy Better for Human and Environmental Health?” here See acast.com/privacy for privacy and opt-out information.
Before I became a doctor, I actually studied Buddhism. I wanted to understand the root of human suffering, and through that understand the way to creating happiness. I realized that by becoming a doctor, I could help people alleviate suffering in multiple ways. Better yet, through Functional Medicine, I could get to the root cause of why the body is struggling and correct it from the ground up. My interest in Buddhism was sparked when my sister took me, at just 15 years old, to a lecture by Professor Robert Thurman, the leading American expert on Tibetan Buddhism. My life has never been the same, and I was thrilled to sit down and tell him that on this episode of The Doctor’s Farmacy. Robert Thurman is the Jey Tsong Khapa Professor of Indo-Tibetan Buddhist Studies in the Department of Religion at Columbia University; President of the Tibet House U.S., a non-profit organization dedicated to the preservation and promotion of Tibetan civilization; and President of the American Institute of Buddhist Studies, a non-profit affiliated with the Center for Buddhist Studies at Columbia University and dedicated to the publication of translations of important artistic and scientific treatises from the Tibetan Tengyur. Time chose Professor Thurman as one of its 25 most influential Americans in 1997, describing him as a “larger than life scholar-activist destined to convey the Dharma, the precious teachings of Shakyamuni Buddha, from Asia to America.”*For context this interview was recorded in April 2020Here are more of the details from our interview: Robert’s description of “Buddhism in a nutshell” (11:04)The first Noble Truth (or fact) of Buddhism: Recognizing that we suffer (15:30)The second Noble Truth (or fact) of Buddhism: Misunderstanding that our reality causes suffering (20:13)The third Noble Truth (or fact) of Buddhism: Freedom from suffering (22:44)The fourth Noble Truth (or fact) of Buddhism: The 8-fold path of education, or training (26:24)Using Buddhism as a lens for dealing with COVID-19 and all the resulting suffering (31:02)Changing our relationship to fear through empathy (37:37)Robert’s experience as a young man, traveling to India, and meeting the Dalai Lama (42:16)Robert’s psychedelic experience and how psychedelics be used to treat and educate (45:21)Book recommendations to go inward, and learn more about Buddhist thought and the environmental movement (59:02)Learn more about Robert Thurman at https://bobthurman.com/Follow Robert on Facebook @Robert.A.F.Thurman and on Twitter @bobthurmanListen to Robert’s podcast at https://bobthurman.com/bob-thurman-podcast/ See acast.com/privacy for privacy and opt-out information.
“I can’t breathe” has become a powerful phrase to symbolize the problem of systemic racism and unchecked prejudiced violence in our country. It’s also a powerful metaphor for the weight of how people feel when it comes to the social, economic, and healthcare inequalities that continue to thrive. And in the age of COVID-19, we keep hearing people say they can’t wait to get back to normal. But if this is what normal has looked like, do we really want it? It’s time for us to get more involved than ever before to create a new normal that includes social justice, civil rights, and compassion.On this episode of The Doctor’s Farmacy, I talked with John Grossenbacher about how to begin this reimagining of America and so much more. John is a Navy veteran, was the Captain of a nuclear attack submarine, and rose to be a Vice Admiral and Commander of the US Submarine Forces. Following the Navy, John became the Director of the Department of Energy’s Idaho National Laboratory (INL). INL is a sprawling industrial-scale research facility that covers 900 square miles and employs 4,000 people. There he led science and engineering research in energy, environmental, national, and homeland security fields. He also advised Governors, Senators, Congressmen, state, and local leaders in the region and Canada on energy, environmental, and homeland security matters.Here are more of the details from our interview: Saving the idea of America (3:08)Monopolization of wealth and industry in America (5:29)Managing our way out of the coronavirus pandemic with competence and compassion (8:37)Reforming America’s broken systems (12:26)They mythology of America and the American dream (16:28)Creating a culture of values (22:55)The impact of technology on our lives (25:39)Do we really want to get back to normal? (28:48)Reforming the food system and why you can’t separate the food system from politics (32:13)Learning from history and science, and John’s book recommendations include, “American Gospel” by John Meacham, “Thinking in Systems” by Donella H. Meadows, and “Trust” by Francis Fukuyama (48:53) See acast.com/privacy for privacy and opt-out information.