In today's VETgirl online veterinary continuing education podcast, we review the usefulness of measuring iron levels in dogs with systemic inflammatory response syndrome (SIRS). Now, you probably don't think you see SIRS or septic cases, but you do. SIRS is a result of overstimulation of the inflammatory cascade (with secondary release of inflammatory mediators). SIRS can be seen due to thermal injury (e.g., heat stroke, burns), immune-mediated disease, etc. and can be seen with neoplasia, pancreatitis, trauma, infectious disease, etc. The definition of SIRS is very loose, unfortunately and includes two of the following criteria: