In this VetGirl podcast, we review tramadol toxicosis in a cat (80 mg/kg!) and the general mechanism of action of how this commonly used, scheduled oral analgesic works. We'll also discuss dosing and what drugs to avoid with concurrent tramadol administration. Most importantly, we'll discuss how to treat tramadol toxicosis, what clinical signs you can see in dogs and cats, and overall treatment for serotonin syndrome (including fluid therapy, cyproheptadine, sedatives, etc.).