Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University. Host: <a href="http://www.virology.ws/">Vincent Racaniello</a> Guest: <a href="https://www.sternberglab.org/">Sam Sternberg</a>  Become a <a href="http://www.patreon.com/microbetv" target="_blank" rel="noopener">Patron of TWiM</a>! Links for this episode <ul> <li><a href="https://www.sternberglab.org/">Sternberg Laboratory</a> at Columbia</li> <li>Mechanism of <a href= "https://www.ncbi.nlm.nih.gov/pubmed/22345129">substrate selection</a> by Cas9 (RNA)</li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/24476820">DNA interrogation </a>by Cas9 (Nature)</li> <li>Conformational control of <a href= "https://www.ncbi.nlm.nih.gov/pubmed/26524520">DNA target cleavage</a> by Cas9 (Nature)</li> <li><a href="https://amzn.to/2ofnvrk">A Crack in Creation</a> by Doudna and Sternberg</li> <li>What if we could <a href="https://youtu.be/BSL3k9ezGoA">rewrite the human genome?</a> (YouTube)</li> <li><a href="http://www.shsternberg.com/">Sam Sternberg</a></li> </ul> Music used on TWiM is composed and performed by <a href= "http://ronaldjenkees.com/" target="_blank" rel="noopener">Ronald Jenkees</a> and used with permission. Send your microbiology questions and comments to <a target="_blank" rel= "noopener">twim@microbe.tv</a>

185: There’s no moa Moa

This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.